PHARMACOKINETICS OF HIGH-DOSE INTRAVENOUS CIPROFLOXACIN IN YOUNG AND ELDERLY AND IN MALE AND FEMALE SUBJECTS

被引：39
|
作者：
SHAH, A [1 ]
LETTIERI, J [1 ]
NIX, D [1 ]
WILTON, J [1 ]
HELLER, AH [1 ]
机构：
[1] MILLARD FILLMORE HOSP,CLIN PHARMACOKINET LAB,BUFFALO,NY 14209
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1995年 / 39卷 / 04期
关键词：
D O I：
10.1128/AAC.39.4.1003
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
The effects of age and gender on the pharmacokinetics of high-dose intravenous ciprofloxacin in a healthy volunteer study were investigated. Plasma ciprofloxacin concentrations were higher in the elderly than in the young, and the pharmacokinetic parameters were not significantly different between the genders. Ciprofloxacin was well tolerated, with the majority of adverse events related to local reactions at the IV site.
引用
收藏
页码：1003 / 1006
页数：4
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