STUDIES ON CARDIOTONIC AGENTS .6. SYNTHESIS OF NOVEL 4,5-DIHYDRO-3(2H)-PYRIDAZINONE DERIVATIVES CARRYING SOME BENZOHETEROCYCLES AT THE 6-POSITION

被引：0
|
作者：
NOMOTO, Y
TAKAI, H
OHNO, T
KUBO, K
机构：
来源：
CHEMICAL & PHARMACEUTICAL BULLETIN | 1991年 / 39卷 / 02期
关键词：
CARDIOTONIC AGENT; STRUCTURE ACTIVITY RELATIONSHIP; PYRIDAZINONE; QUINAZOLINE; BENZOTHIAZOLE; IMIDAZOBENZOTHIAZOLE; BENZOTHIOPHENE; BENZOTHIENOPYRIMIDINE;
D O I：
暂无
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Several benzothiazolyl, imidazobenzothiazolyl, benzothienyl, benzothienopyrimidinyl and quinazolinyl 4,5-dihydro-3(2H)-pyridazinones were synthesized and examined for cardiotonic activity in anesthetized dogs after i.v. administration. Among them, 4-methylamino-7-(2,3,4,5-tetrahydro-5-methyl-3-oxo-6-pyridazinyl)quinazoline (36) showed potent and long-lasting inotropic activity (relative potency = 2.11, milrinone = 1). The activity of 36 was more potent that indolidan (2) (relative potency = 1.53) which is one of the most potent inotropic agents to date.
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收藏
页码：352 / 357
页数：6
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