GENETIC-RECOMBINATION BETWEEN MALIGNANT HYPERTHERMIA AND CALCIUM RELEASE CHANNEL IN SKELETAL-MUSCLE

被引：0
|
作者：
FAGERLUND, T
ISLANDER, G
RANKLEV, E
HARBITZ, I
HAUGE, JG
MOKLEBY, E
BERG, K
机构：
[1] UNIV OSLO,INST MED GENET,POB 1036 BLINDERN,N-0315 OSLO,NORWAY
[2] UNIV LUND,DEPT ANESTHESIOL,S-22101 LUND,SWEDEN
[3] NORWEGIAN COLL VET MED,DEPT BIOCHEM,OSLO 1,NORWAY
来源：
CLINICAL GENETICS | 1992年 / 41卷 / 05期
关键词：
CALCIUM RELEASE CHANNEL; CANDIDATE GENES; GENETICS; HETEROGENEITY; LINKAGE; MALIGNANT HYPERTHERMIA; RECOMBINATION;
D O I：
暂无
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Absolute linkage between the gene, on chromosome 19, for the calcium release channel (CRC) of the sarcoplasmic reticulum in skeletal muscle and malignant hyperthermia (MH) has been reported by other workers. In the present study of three Swedish Families informative with respect to this linkage relationship, definite recombinants were found in two families. We conclude that mutations in other genes than the CRC gene can cause the clinical picture of MH. Accordingly, MH appears to be genetically heterogeneous.
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页码：270 / 272
页数：3
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