IMPORTANCE OF SECONDARY TXA2 RELEASE IN MEDIATING OF ENDOTHELIN-1 INDUCED BRONCHOCONSTRICTION AND VASOPRESSIN IN THE GUINEA-PIG

被引：15
|
作者：
LUEDDECKENS, G
BIGL, H
SPERLING, J
BECKER, K
BRAQUET, P
FORSTER, W
机构：
[1] ROBERT KOCH HOSP LUNG DIS,W-7031 LEIPZIG,GERMANY
[2] INST HENRI BEAUFOUR,F-92350 IE PLESSIS ROBINS,FRANCE
来源：
PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS | 1993年 / 48卷 / 03期
关键词：
D O I：
10.1016/0952-3278(93)90095-E
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The i.v. bolus application of 1 nmol/kg endothelin-1 (ET-1) in anaesthetized and ventilated guinea-pigs caused an increase in mean arterial blood pressure (BP) and a bronchoconstriction. Both have been reduced or abolished hy COX inhibition (ASA) or substances specifically reducing the thromboxane A2 (TXA2) generation (HOE 944) or receptor binding (BM 13177). The significant increase in TXB, concentrations in plasma and bronchoalveolar lavage (BAL) after ET-1 challenge (15-fold and 4-fold, respectively) have been reduced or abolished by ASA as well as HOE 944 and not altered by BM 13177.
引用
收藏
页码：261 / 263
页数：3
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