PROTECTIVE EFFECT OF COPPER AGAINST CADMIUM CYTOTOXICITY ON CULTURED VASCULAR ENDOTHELIAL-CELLS

被引：0

作者：

KAJI, T ^{[1
]}

FUJIWARA, Y ^{[1
]}

KOYANAGI, E ^{[1
]}

YAMAMOTO, C ^{[1
]}

MISHIMA, A ^{[1
]}

SAKAMOTO, M ^{[1
]}

KOZUKA, H ^{[1
]}

机构：

[1] TOYAMA MED & PHARMACEUT UNIV,FAC PHARMACEUT SCI,TOXICOL SECT,SUGITANI,TOYAMA 93001,JAPAN

来源：

TOXICOLOGY LETTERS | 1992年 / 63卷 / 01期

关键词：

CADMIUM; COPPER; CYTOTOXICITY; ENDOTHELIAL CELLS; ENDOTHELIUM; VASCULAR;

D O I：

暂无

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

We investigated the effect of copper on cadmium-induced cytotoxicity on vascular endothelial cells from bovine aorta in a culture system. Cytotoxicity was evaluated by the [H-3]adenine release assay and the histological observation. After a 24-h incubation, cadmium exhibited a significant cytotoxicity on confluent cultures of endothelial cells in a dose-dependent manner, while copper only slightly did after a 24-h incubation. It was found that copper (5 muM) significantly decreased cadmium (1 and 2 muM) cytotoxicity; histologically, formation of de-endothelialized areas in the cell layer caused by cadmium was reduced by copper. The accumulation of cadmium in the cell layer was significantly decreased by copper; however, that of copper was unaffected by cadmium. It was therefore suggested that copper significantly protects cadmium-induced cytotoxicity on cultured endothelial cells primarily through decreasing the cellular cadmium accumulation.

引用

页码：13 / 20

页数：8

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