COMPARISON OF PROPOFOL AND KETOFOL (COMBINATION OF KETAMINE AND PROPOFOL) FOR MODIFIED ELECTROCONVULSIVE THERAPY

BACKGROUND Propofol and ketamine are used in modified electroconvulsive therapy (ECT) in treating various psychiatric disorders. Propofol shortens seizure duration. Ketamine might cause cardiotoxicity, delayed recovery and psychotic episodes. This study was designed to evaluate the effects of propofol and ketofol as an intravenous anaesthetic agent on seizure duration, recovery time and haemodynamic variables during modified electroconvulsive therapy. MATERIALS AND METHODS In this prospective study, sixty patients aged 18-65 years with ASA I/II, for psychiatric disorders were included. Patients were divided into two groups (30 each). Group P received propofol and group K received ketofol. Seizure duration, recovery time, haemodynamic variables, complications and side effects were recorded. Data was analysed with SPSS 21 and independent t-test. p<0.05 was considered significant. RESULTS Induction time was significant earlier (p<0.001) in group K (20.23 +/- 6.84 seconds) as compared to group P (33.43 +/- 13.40 seconds). The mean duration of seizure of patients of group K (38.93 +/- 15.26 seconds) was found to be statistically significantly higher (p<0.001) than that of group P (18.10 +/- 5.17 seconds). The duration of recovery time was significantly earlier (p<0.001) in group K (9.30 +/- 3.01 min) patients as compared to group P (18.93 +/- 1.46 min) patients. Patients in Ketofol group were more haemodynamically stable than patients in propofol group. CONCLUSION Ketofol (1: 1 Ketamine +propofol mixture) was associated with longer mean seizure, shorter recovery times with better haemodynamic stability as compared to propofol in modified ECT anaesthesia.