D-ALANINE INHIBITS METHAMPHETAMINE-INDUCED HYPERACTIVITY IN RATS

被引：0
|
作者：
HASHIMOTO, A
NISHIKAWA, T
OKA, T
TAKAHASHI, K
机构：
[1] NATL INST NEUROSCI,NATL CTR NEUROL & PSYCHIAT,DIV MENTAL DISORDER RES,4-1-1 OGAWA HIGASHI,TOKYO 187,JAPAN
[2] NIPPON OIL & FATS CO LTD,TSUKUBA RES LAB,TSUKUBA,IBARAKI 30026,JAPAN
来源：
EUROPEAN JOURNAL OF PHARMACOLOGY | 1991年 / 202卷 / 01期
关键词：
METHAMPHETAMINE; D-ALANINE; L-ALANINE; LOCOMOTOR ACTIVITY; STRYCHNINE-INSENSITIVE GLYCINE BINDING SITE; NMDA RECEPTOR COMPLEX;
D O I：
暂无
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Bilateral intracerebroventricular injection of D-alanine (200-600-mu-g/rat) antagonized the ability of methamphetamine (1.0 mg/kg s.c.) to induce locomotor stimulation in the rat. In contrast, L-alanine (600-mu-g/rat) failed to affect the behavioral change induced by methamphetamine. The stereoselectivity parallels the potency of these amino acids as agonists for the strychnine-insensitive glycine binding site within the NMDA receptor complex. These results support the view that reduced excitatory amino acidergic neurotransmission may be involved in methamphetamine-induced hyperactivity.
引用
收藏
页码：105 / 107
页数：3
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