FOLLICULAR TOXIC PUSTULODERMA ASSOCIATED WITH ALLOPURINOL

Allopurinol is widely prescribed for primary and secondary hyperuricaemia, and cutaneous adverse reactions are seen in 0.8-2.1% of recipients.1,2 The majority of these are mild and include pruritus, diffuse or maculo-papular erythema, urticaria and ichthyosis.3 More severe reactions are well recognized and include exfoliative dermatitis, toxic epidermal necrolysis and a generalized hypersensitivity syndrome.3-5 The latter typically comprises fever, rash, hepatic and renal dysfunction and eosinophil leucocytosis.5 The occurrence of toxic pustuloderma due to allopurinol, confirmed by re-challenge, is reported.