FORMULATION AND RELEASE KINETICS OF SUSTAINED-RELEASE PHENYLPROPANOLAMINE HYDROCHLORIDE GRANULES AND TABLETS

被引:2
|
作者
HASHEM, FM
ELSHABOURY, MH
GABR, KE
机构
[1] Pharmaceutics Department, Faculty of Pharmacy, Mansoura University, Mansoura
关键词
D O I
10.3109/03639049409038394
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
Sustained release phenylpropanolamine hydrochloride (PPH) granules and tablets were prepared using HPMC, HPMC and SCMC, Eudragit RS, Eudragit RS+L or HPMC + Eudragit RS matrices. The release pattern of PPH from the prepared granules and tablets was found to be in the following order HPMC > HPMC + SCMC > RS > RS+1 > HPMC + RS. The results revealed that, although the drug concentration was kept constant in all the prepared granules and tablets, the drug release from these formulations was clearly different and depends mainly on the type of matrix used. The presence of Eudragit L with Eudragit RS and Eudragit RS with HPMC resulted in a marked decrease in the drug release compared with that obtained from the matrix containing HPMC or Eudragit RS alone. The release data of PPH from the prepared granules and tablets were treated mathematically according to zero order, first order, Langenbucher, modified Langenbucher and Higuchi models, The results revealed that no one model was able adequately to describe the drug release profiles from these formulations. In-vivo studies in human volunteers showed that, the peak urinary excretion of PPH occurred over a sustained period from 2 to 6.5 hr in case of HPMC + SCMC tablets and from 2 to 10 hr in case of either RS + L or HPMC + RS tablets.
引用
收藏
页码:1795 / 1809
页数:15
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