APPLICATION OF SUPERCRITICAL-FLUID EXTRACTION AND SUPERCRITICAL-FLUID CHROMATOGRAPHY TO THE PRODUCTION OF TAXANES AS ANTICANCER DRUGS

被引：0
|
作者：
HEATON, DM
BARTLE, KD
RAYNER, CM
CLIFFORD, AA
机构：
来源：
HRC-JOURNAL OF HIGH RESOLUTION CHROMATOGRAPHY | 1993年 / 16卷 / 11期
关键词：
SUPERCRITICAL FLUID EXTRACTION; SUPERCRITICAL FLUID CHROMATOGRAPHY; SUPERCRITICAL FLUID COSOLVENT (MODIFIER); FUSED SILICA OPEN TUBULAR CAPILLARY COLUMN; LIQUID SOLVENT EXTRACTION; TIMED-SPLIT INJECTION; RESTRICTOR; FLAME IONIZATION DETECTOR (FID);
D O I：
暂无
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
The supercritical fluid extraction (SFE) of taxicin from the dried needles of the English yew tree, Taxus baccata is described. Analysis by supercritical fluid chromatography (SFC) and proton NMR spectroscopy was used to confirm identity and purity. The extraction efficiency of SFE is comparable with that obtained using liquid solvents. Such taxanes may be used semi-synthetically to prepare potential anti-cancer drugs.
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页码：666 / 670
页数：5
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