Epigenetics in allergic diseases and asthma

被引：5
|
作者：
Castro-Rodriguez, Jose A. [1 ,2 ]
Krause, Bernardo J. [2 ,3 ]
Uauy, Ricardo [1 ,2 ]
Casanello, Paola [1 ,2 ,3 ]
机构：
[1] Pontificia Univ Catolica Chile, Fac Med, Div Pediat, Santiago, Chile
[2] Ctr Invest Med, Lab Programac & Epigenet Perinatal, Santiago, Chile
[3] Pontificia Univ Catolica Chile, Fac Med, Div Obstet & Ginecol, Santiago, Chile
来源：
REVISTA CHILENA DE PEDIATRIA-CHILE | 2016年 / 87卷 / 02期
关键词：
Epigenetic; Asthma; Allergic diseases; Environmental factors; Children; In-utero;
D O I：
10.1016/j.rchipe.2016.02.006
中图分类号：
R72 [儿科学];
学科分类号：
100202 ;
摘要：
Allergic diseases and asthma are the result of complex interactions between genetic predisposition and environmental factors. Asthma is one of the most prevalent chronic disease among children. In this article we review some environmental factors like: allergen exposition, tobacco, bacteria, microbial components, diet, obesity and stress, which influences during intrauterine and infancy life in the epigenetic regulation of asthma and allergic diseases. The review has been done in three models: in-vitro, animal and human. (C) 2016 Sociedad Chilena de Pediatria. Published by Elsevier Espana, S.L.U. This is an open access article under the CC BY-NC-ND license.
引用
收藏
页码：88 / 95
页数：8
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