ELECTROSPRAY IONIZATION MASS-SPECTROMETRY OF PLATINUM ANTICANCER AGENTS

被引：33
|
作者：
POON, GK [1 ]
MISTRY, P [1 ]
LEWIS, S [1 ]
机构：
[1] FINNIGAN MAT CORP,SAN JOSE,CA 95134
来源：
BIOLOGICAL MASS SPECTROMETRY | 1991年 / 20卷 / 11期
关键词：
D O I：
10.1002/bms.1200201106
中图分类号：
Q6 [生物物理学];
学科分类号：
071011 ;
摘要：
Quantification and identification of platinum drugs and their metabolites in biological samples has always been difficult because these compounds are thermally unstable, non-volatile and insoluble. We have demonstrated that electrospray ionization mass spectrometry can be a valuable technique for direct mass spectral analysis of platinum anticancer agents and for obtaining structural information as a result of fragmentation. Full-scan spectra were obtained with approximately 10 pmol samples. These results show the potential of applying this technique in pharmacokinetic studies of platinum anticancer drugs.
引用
收藏
页码：687 / 692
页数：6
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