ALLELE DIVERSITY OF THE H-RAS-1 VARIABLE NUMBER OF TANDEM REPEATS IN NORWEGIAN LUNG-CANCER PATIENTS

被引：10
|
作者：
RYBERG, D
TEFRE, T
SKAUG, V
STANGELAND, L
OVREBO, S
NAALSUND, A
BORRESEN, AL
HAUGEN, A
机构：
[1] NORWEGIAN RADIUM HOSP,DEPT GENET,N-0310 OSLO,NORWAY
[2] HAUKELAND HOSP,N-5021 BERGEN,NORWAY
[3] NATL HOSP,N-0027 OSLO,NORWAY
来源：
ENVIRONMENTAL HEALTH PERSPECTIVES | 1992年 / 98卷
关键词：
D O I：
10.2307/3431267
中图分类号：
X [环境科学、安全科学];
学科分类号：
08 ; 0830 ;
摘要：
We have examined restriction fragment length polymorphisms of the H-ras-I gene in germ-line DNA from 214 lung cancer patients and 309 unaffected controls. When DNA samples were digested with MspI/HpaII, Southern blot analysis revealed at least 22 different alleles, grouped according to their frequencies as common, intermediate, and rare. The frequency of rare alleles in lung cancer patients (16/428) is significantly different (p = 0.002) from that in the control group (5/618). Individuals with rare alleles were found to be at 4.7-fold greater risk of lung cancer than those with no rare alleles.
引用
收藏
页码：187 / 189
页数：3
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