SALICYLALDOXIME BLOCKS K+ AND CA2+ CURRENTS IN RAT CARDIAC MYOCYTES

被引：5
|
作者：
KARHU, S
PERTTULA, S
WECKSTROM, M
KIVISTO, T
SELLIN, LC
机构：
[1] UNIV OULU,DEPT PHYS SCI,DIV BIOPHYS,SF-90570 OULU,FINLAND
[2] UNIV OULU,DEPT PHYSIOL,SF-90220 OULU,FINLAND
来源：
EUROPEAN JOURNAL OF PHARMACOLOGY | 1995年 / 279卷 / 01期
关键词：
ANTIARRHYTHMIC; ACTION POTENTIAL; CA2+ CURRENT; K+ CURRENT; OXIME; CARDIAC MYOCYTE;
D O I：
10.1016/0014-2999(95)00131-4
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The effects of salicylaldoxime, 2-(OH)C6H4CH = NOH, on the action potential duration, transient outward K+ current and slow inward Ca2+ current were studied in isolated rat ventricular myocytes. The application of salicylaldoxime (0.1-2.0 mM) reversibly increased the action potential duration and reduced in a dose-dependent manner both the transient outward K+ and the slow inward Ca2+ currents. The effect of salicylaldoxime on these two ionic currents was similar to that of 2,3-butanedione monoxime, but was about ten times more potent. Compounds which block both K+ and Ca2+ currents may represent a new type of Class III antiarrhythmic agent which counteracts arrhythmias initiated by re-entry with reduced proarrhythmic risk via triggered activity.
引用
收藏
页码：7 / 13
页数：7
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