ANTITUMOR-ACTIVITY OF HOMO-AZA-STEROIDAL ESTERS OF P-N,N-BIS(2-CHLOROETHYL)AMINOPHENOXYACETIC ACID

The homo - aza - steroidal esters of carboxylic derivatives of N, N - bis (2 - chloroethyl) aniline are reviewed. In particular, we discuss the antitumor activity of the esters of homo - aza steroids in which the p - N, N - bis (2 - chloroethyl) aminophenoxyacetic acid is linded to the C - 3 or C - 17 position, while the lactam nucleus is linked to the D or A ring of the modified steroid respectively. The current literature indicates clearly that the potential of these esters is due to the synergistic activity of both the lactam and the p - N, N - bis (2 - chloroethyl) aminophenoxyacetic acid.