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FACILE AND EFFICIENT SYNTHESES OF NOVEL (S)-3-FLUOROPYRROLIDINE AND (R)-3-FLUOROPYRROLIDINE AND 3,3-DIFLUOROPYRROLIDINE

被引：0
|
作者：
GIARDINA, G
DONDIO, G
GRUGNI, M
机构：
来源：
SYNLETT | 1995年 / 01期
关键词：
3-FLUOROPYRROLIDINE; 3,3-DIFLUOROPYRROLIDINE; POTASSIUM FLUORIDE; DIETHYLAMINOSULFUR TRIFLUORIDE; KAPPA-OPIOID AGONISTS;
D O I：
暂无
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Novel enantiomeric 3-fluoropyrrolidines and 3,3-difluoropyrrolidine were obtained in high yield starting from the enantiomerically pure and commercially available (2S,4R)-4-hydroxyproline. Spray-dried potassium fluoride and diethylaminosulfur trifluoride (DAST) were used to introduce one or two fluorine atoms, respectively.
引用
收藏
页码：55 / 57
页数：3
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