Bloom syndrome: research and data priorities for the development of precision medicine as identified by some affected families

被引:13
|
作者
Campbell, Mary Beth [1 ,2 ]
Campbell, Wesley C. [1 ,3 ]
Rogers, James [1 ]
Rogers, Natalie [1 ]
Rogers, Zachary [1 ]
van den Hurk, Anne Marie [1 ]
Webb, Annie [1 ]
Webb, Talon [1 ]
Zaslaw, Paul [1 ]
机构
[1] Childrens Canc Therapy Dev Inst, Pediat Canc Nanocourse 2017, Beaverton, OR 97005 USA
[2] CALTECH, Caltech Off Technol Transfer & Corp Partnerships, Pasadena, CA 91125 USA
[3] Univ Calif Los Angeles, Dept Phys & Astron, Los Angeles, CA 90095 USA
来源
关键词
D O I
10.1101/mcs.a002816
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Bloom syndrome (BS) is a rare, autosomal recessive genetic disorder characterized by short stature, a skin rash associated with sun exposure, and an elevated likelihood of developing cancers of essentially all types, beginning at an early age. Cancer is the leading cause of death for persons with BS, and its early onset results in a reported median lifespan of <30 years. With fewer than 300 documented cases since BS was first described in 1954, its rarity has challenged progress in advancing both the care of and the cure for persons with BS. Presently, there are no known clinically actionable targets specific to persons with this cancer predisposition syndrome, despite the fact that standard cancer treatments are often contraindicated or must be substantially modified for persons with BS. Herein, Zachary Rogers recounts his experience as a cancer patient with BS contemplating a substantially customized chemotherapy regimen that highlights the need for development of individualized treatments in the BS community. We also outline a patient-centered research and community action road map with the goal of improving and prolonging the lives of persons with Bloom syndrome, including the facilitation of precision medicine development specific to this condition.
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页数:11
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