CHLORISONDAMINE, A NONCOMPETITIVE GANGLIONIC BLOCKER, ANTAGONIZES THE CARDIOVASCULAR EFFECTS OF COCAINE IN CONSCIOUS SQUIRREL-MONKEYS

被引：9
|
作者：
TELLA, SR [1 ]
SCHINDLER, CW [1 ]
GOLDBERG, SR [1 ]
机构：
[1] GEORGETOWN UNIV,SCH MED,DEPT PHARMACOL,WASHINGTON,DC 20007
来源：
PHARMACOLOGICAL RESEARCH | 1993年 / 27卷 / 03期
关键词：
COCAINE; BLOOD PRESSURE; HEART RATE; GANGLIONIC BLOCKADE; CHLORISONDAMINE; CENTRAL NERVOUS SYSTEM (SQUIRREL MONKEYS);
D O I：
10.1006/phrs.1993.1022
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Cocaine (0.3 mg/kg i.v.) produced prolonged pressor and tachycardiac responses in conscious squirrel monkeys. Peak pressor and tachycardiac responses following cocaine were 32.7 ± 3.3 mm Hg and 78.8 ± 7.4 beats/min, respectively. Pretreatment with 1 mg/kg chlorisondamine, a noncompetitive ganglionic blocker, attenuated the pressor (18.3 ± 3.8 mm Hg) and tachycardiac (63.7 ± 10 beats/min) effects of cocaine, while 5 mg/kg chlorisondamine completely prevented these effects of cocaine. This finding supports the conclusion that the cardiovascular effects of cocaine are centrally mediated. © 1993 Academic Press. All rights reserved.
引用
收藏
页码：233 / 239
页数：7
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