FUNCTIONAL-CHARACTERIZATION AND DEVELOPMENTAL REGULATION OF MOUSE TELOMERASE RNA

被引：337
|
作者：
BLASCO, MA
FUNK, W
VILLEPONTEAU, B
GREIDER, CW
机构：
[1] COLD SPRING HARBOR LAB, COLD SPRING HARBOR, NY 11724 USA
[2] GERON CORP, MENLO PK, CA 94025 USA
来源：
SCIENCE | 1995年 / 269卷 / 5228期
关键词：
D O I：
10.1126/science.7544492
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Telomerase synthesizes telomeric DNA repeats onto chromosome ends de novo. The mouse telomerase RNA component was cloned and contained only 65 percent sequence identity with the human telomerase RNA. Alteration of the template region in vivo generated altered telomerase products. The shorter template regions of the mouse and other rodent telomerase RNAs could account for the shorter distribution of products (processivity) generated by the mouse enzyme relative to the human telomerase. Amounts of telomerase RNA increased in immortal cells derived from primary mouse fibroblasts. RNA was detected in all newborn mouse tissues tested but was decreased during postnatal development.
引用
收藏
页码：1267 / 1270
页数：4
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