PERMEATION OF PIROXICAM AND PIROXICAM-BETA-CYCLODEXTRIN THROUGH ARTIFICIAL MEMBRANES

被引：0
|
作者：
BETTINI, R [1 ]
SANTI, P [1 ]
CATELLANI, PL [1 ]
MASSIMO, G [1 ]
BELLOTTI, A [1 ]
BARTHELEMY, C [1 ]
GUYOTHERMANN, AM [1 ]
TRUBLIN, F [1 ]
COLOMBO, P [1 ]
机构：
[1] DIPARTIMENTO FARMACEUT,VIA M AZEGLIO 85,I-43100 PARMA,ITALY
来源：
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS | 1992年 / 38卷 / 06期
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D O I：
暂无
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Transport of piroxicam through membranes in the presence of beta-cyclodextrin can be affected by the equilibrium between free drug and that included and by its distribution between oil and water phases. The aim of this work was to study the influence of beta-cyclodextrin on transport of piroxicam through an artificial lipid membrane, from buffer solutions with a pH value ranging from 1.2 to 7.4. The results obtained reveal a considerable positive influence of beta-cyclodextrin on the piroxicam flux because of its effect on drug solubility. This influence on flux depends on the pH value and is particularly evident at pH 1.2 and 7.4, whereas it is negligible at pH 5.0 at which the solubility of the compound is lowest and the stability constant highest. Beta-cyclodextrin permeates the lipid membranes employed to a significant degree.
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页码：203 / 208
页数：6
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