PROTEIN TARGETS FOR STRUCTURE-BASED DRUG DESIGN

被引：31
|
作者：
WALKINSHAW, MD
机构：
[1] Sandoz Pharma AG, Basel
来源：
MEDICINAL RESEARCH REVIEWS | 1992年 / 12卷 / 04期
关键词：
D O I：
10.1002/med.2610120403
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The aim of this review is to discuss those proteins for which the known 3D structure may be relevant to drug design. The majority of available information to date is from protein x-ray crystallography, though a growing number of studies are based on molecular modeling and NMR spectroscopy. The review concentrates on major progress reported in the literature from 1985 through the first half of 1991. Protein structures and related drug design studies have been loosely classified here into a number of major therapeutic areas: immunology, inflammation, cardiovascular disorders, cancer, viral and bacterial infection. Table I [GRAPHICS] lists those proteins discussed in this review for which 3D structural information is available.
引用
收藏
页码：317 / 372
页数：56
相关论文
共 50 条
  • [1] PROTEIN SURFACES AS TARGETS FOR STRUCTURE-BASED DRUG DESIGN
    JAMESON, BA
    MCDONNELL, JM
    WIADERKIEWICZ, R
    KORNGOLD, R
    BASERGA, R
    [J]. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1994, 207 : 178 - COMP
  • [2] leadXPro - Structure-Based Drug Design on Membrane Protein Targets at SwissFEL
    Cheng, Robert
    Markovic, Sandra
    Botte, Mathieu
    Hennig, Michael
    [J]. ACTA CRYSTALLOGRAPHICA A-FOUNDATION AND ADVANCES, 2016, 72 : S211 - S211
  • [3] PROTEIN STRUCTURE-BASED DRUG DESIGN
    WHITTLE, PJ
    BLUNDELL, TL
    [J]. ANNUAL REVIEW OF BIOPHYSICS AND BIOMOLECULAR STRUCTURE, 1994, 23 : 349 - 375
  • [4] From Laptop to Benchtop to Bedside: Structure-based Drug Design on Protein Targets
    Chen, Lu
    Morrow, John K.
    Tran, Hoang T.
    Phatak, Sharangdhar S.
    Du-Cuny, Lei
    Zhang, Shuxing
    [J]. CURRENT PHARMACEUTICAL DESIGN, 2012, 18 (09) : 1217 - 1239
  • [5] Structure-based drug design: From nucleic acid to membrane protein targets
    Dailey, Magdalena M.
    Hait, Chayanendu
    Holt, Patrick A.
    Maguire, Jon M.
    Meier, Jason B.
    Miller, M. Clarke
    Petraccone, Luigi
    Trent, John O.
    [J]. EXPERIMENTAL AND MOLECULAR PATHOLOGY, 2009, 86 (03) : 141 - 150
  • [6] Structure-based drug discovery and protein targets in the CNS
    Hubbard, Roderick E.
    [J]. NEUROPHARMACOLOGY, 2011, 60 (01) : 7 - 23
  • [7] Towards structure-based protein drug design
    Zhang, Changsheng
    Lai, Luhua
    [J]. BIOCHEMICAL SOCIETY TRANSACTIONS, 2011, 39 : 1382 - 1386
  • [8] Binding Site Detection and Druggability Prediction of Protein Targets for Structure-Based Drug Design
    Yuan, Yaxia
    Pei, Jianfeng
    Lai, Luhua
    [J]. CURRENT PHARMACEUTICAL DESIGN, 2013, 19 (12) : 2326 - 2333
  • [9] Structure-based drug discovery enabled for membrane protein targets
    Hennig, Michael
    [J]. ACTA CRYSTALLOGRAPHICA A-FOUNDATION AND ADVANCES, 2021, 77 : C1107 - C1107
  • [10] A protein crystallization strategy for structure-based drug design
    Bergfors, Terese
    [J]. ACTA CRYSTALLOGRAPHICA A-FOUNDATION AND ADVANCES, 2019, 75 : A46 - A46
12345