Functional diversity of long non-coding RNAs in immune regulation

被引：65
|
作者：
Geng, Hua [1 ,2 ]
Tan, Xiao-Di [1 ,2 ,3 ]
机构：
[1] Ann & Robert H Lurie Childrens Hosp Chicago, Ctr Intestinal & Liver Inflammat Res, Stanley Manne Childrens Res Inst, 225 E Chicago Ave,Box 217, Chicago, IL 60611 USA
[2] Northwestern Univ, Dept Pediat, Feinberg Sch Med, Chicago, IL 60611 USA
[3] Northwestern Univ, Dept Pathol, Feinberg Sch Med, Chicago, IL 60611 USA
来源：
GENES & DISEASES | 2016年 / 3卷 / 01期
基金：
美国国家卫生研究院;
关键词：
Immune regulation; LncRNAs;
D O I：
10.1016/j.gendis.2016.01.004
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Precise and dynamic regulation of gene expression is a key feature of immunity. In recent years, rapid advances in transcriptome profiling analysis have led to recognize long non-coding RNAs (lncRNAs) as an additional layer of gene regulation context. In the immune system, lncRNAs are found to be widely expressed in immune cells including monocytes, macrophages, dendritic cells (DC), neutrophils, T cells and B cells during their development, differentiation and activation. However, the functional importance of immune-related lncRNAs is just emerging to be characterized. In this review, we discuss the up-to-date knowledge of lncRNAs in immune regulation. Copyright (C) 2016, Chongqing Medical University. Production and hosting by Elsevier B.V.
引用
收藏
页码：72 / 81
页数：10
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