CANCER OF THE ANAL-CANAL - TREATMENT WITH CHEMOTHERAPY AND LOW-DOSE RADIATION-THERAPY

被引：23
|
作者：
SMITH, DE
SHAH, KH
RAO, AR
FROST, DB
LATINO, F
ANDERSON, PJ
PEDDADA, AV
KAGAN, AR
机构：
[1] KAISER PERMANENTE MED CTR,DEPT RADIAT ONCOL,LOS ANGELES,CA 90027
[2] KAISER PERMANENTE MED CTR,DEPT SURG,LOS ANGELES,CA 90027
[3] KAISER PERMANENTE MED CTR,DEPT INTERNAL MED,LOS ANGELES,CA 90027
来源：
RADIOLOGY | 1994年 / 191卷 / 02期
关键词：
ANUS; NEOPLASMS; THERAPEUTIC RADIOLOGY;
D O I：
10.1148/radiology.191.2.8153343
中图分类号：
R8 [特种医学]; R445 [影像诊断学];
学科分类号：
1002 ; 100207 ; 1009 ;
摘要：
PURPOSE: To determine the efficacy of a standardized protocol of chemotherapy and low-dose radiation therapy in treatment of patients with anal canal cancer. MATERIALS AND METHODS: Forty-two consecutive patients with anal canal cancer were treated with 15 fractions of 30-Gy photon beam radiation therapy administered anteroposterior-posteroanterior in conjunction with chemotherapy with 5-fluorouracil and mitomycin C. Survival analysis was performed with the lifetest procedure. RESULTS: In patients with stage T1 and T2 tumors, 26 of 29 (90%) were free of disease after chemotherapy and radiation therapy and had no recurrent tumors. In patients with stage T3 and T4 tumors, five of 13 (38%) were free of disease after therapy and had no recurrences. CONCLUSION: This therapy is effective for epidermoid cancers of the anal canal that are smaller than 5 cm regardless of nodal status. Tumors larger than this or that invade adjacent structures are not adequately controlled with this protocol.
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页码：569 / 572
页数：4
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