THE MECHANISM OF AIRWAY HYPERRESPONSIVENESS FOLLOWING IMMEDIATE ASTHMATIC RESPONSE IN OVALBUMIN-SENSITIZED GUINEA-PIGS

被引：0
|
作者：
MINOGUCHI, K [1 ]
ADACHI, M [1 ]
KOBAYASHI, T [1 ]
TAKAHASHI, T [1 ]
机构：
[1] SHOWA UNIV,SCH MED,DEPT INTERNAL MED 1,1-5-8 HATANODAI,SHINAGAWA KU,TOKYO 142,JAPAN
来源：
JOURNAL OF LIPID MEDIATORS | 1992年 / 5卷 / 02期
关键词：
IMMEDIATE ASTHMATIC RESPONSE; AIRWAY HYPERRESPONSIVENESS; BETA-ADRENOCEPTOR DYSFUNCTION; THROMBOXANE-A2; PLATELET-ACTIVATING FACTOR;
D O I：
暂无
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The mechanism of airway hyperresponsiveness (AH) following immediate asthmatic response (IAR) was investigated in ovalbumin (OA)-sensitized guinea-pigs. After IAR, airway responsiveness was significantly increased and propranolol-induced bronchoconstriction (PIB) was so severe that guinea-pigs died. A thromboxane (Tx) synthetase inhibitor CS-518 significantly inhibited AH and PIB, whereas a PAF receptor antagonist WEB-2086 was only slightly effective. These results suggest that TxA2 plays an important role and PAF a partial role in AH following IAR.
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页码：169 / 172
页数：4
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