THE MULTIFUNCTIONAL TFIIH COMPLEX AND TRANSCRIPTIONAL CONTROL

被引：86
|
作者：
DRAPKIN, R
REINBERG, D
机构：
[1] R. Drapkin and D. Reinberg are at the Howard Hughes Medical Institute, Department of Biochemistry, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, 675 Hoes Lane, Piscataway
来源：
TRENDS IN BIOCHEMICAL SCIENCES | 1994年 / 19卷 / 11期
关键词：
D O I：
10.1016/0968-0004(94)90139-2
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
RNA polymerase II (Pol II) requires seven general transcription factors (GTFs) and ATP for transcription initiation. Transcription factor IIH (TFIIH) has emerged as the sole GTF with enzymatic activity. In addition to its essential role in transcription initiation, recent studies have demonstrated a direct involvement of TFIIH in DNA excision repair processes. The enzymatic properties and functional duality of TFIIH make it a prime target for regulation by viral and cellular factors.
引用
收藏
页码：504 / 508
页数：5
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