ACUTE FATAL MYELOENCEPHALOPATHY AFTER COMBINED INTRATHECAL CHEMOTHERAPY IN A CHILD WITH ACUTE LYMPHOBLASTIC-LEUKEMIA

被引：27
|
作者：
VONDERWEID, NX
DECROUSAZ, H
BECK, D
DEONNA, T
MIKLOSSY, J
JANZER, RC
机构：
[1] HOP ENFANCE,LAUSANNE,SWITZERLAND
[2] UNIV LAUSANNE,INST PATHOL,DIV NEUROPATHOL,CH-1000 LAUSANNE 17,SWITZERLAND
[3] CHU VAUDOIS,DEPT PEDIAT,NEUROPEDIAT UNIT,CH-1011 LAUSANNE,SWITZERLAND
来源：
MEDICAL AND PEDIATRIC ONCOLOGY | 1991年 / 19卷 / 03期
关键词：
METHOTREXATE; CYTOSINE ARABINOSIDE; CEREBROSPINAL FLUID;
D O I：
10.1002/mpo.2950190309
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
We report a case of a fatal toxic encephalomyelopathy in a 12-year-old girl due to prophylactic intrathecal injection of methotrexate and cytosine arabinoside, with a characteristic progressive symptomatology leading to death after 28 days. The location and type of neuropathological changes support the hypothesis of a direct toxic effect of methotrexate and/or cytosine arabinoside on structures directly exposed to the cerebrospinal fluid.
引用
收藏
页码：192 / 198
页数：7
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