SYNTHESIS AND CONFORMATIONAL-ANALYSIS OF STEREOISOMERIC 1-METHYL AND 2-METHYL 2H,4H-1,6,7,11B-TETRAHYDRO-1,3-OXAZINO[4,3-A]ISOQUINOLINES

被引：0

作者：

SOHAR, P

LAZAR, L

FULOP, F

BERNATH, G

KOBOR, J

机构：

[1] EOTVOS LORAND UNIV, ALTALANOS & SZERVETLEN KEM TANSZEK, H-1518 BUDAPEST 112, HUNGARY

[2] JUHASZ GYULA TANARKEPZO FOISKOLA, KEM TANSZEK, H-6720 SZEGED, HUNGARY

[3] SZENT GYORGYI ALBERT ORVOSTUDOMANYI EGYET, GYOGYSZERESZI VEGYTANI INTEZET, H-6701 SZEGED, HUNGARY

来源：

MAGYAR KEMIAI FOLYOIRAT | 1993年 / 99卷 / 01期

关键词：

D O I：

暂无

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Starting form diastereomerically pure 1-(beta-hydroxyethyl-)-1'-methyl- or 2'-methyl-6,7-di-methoxy-1,2,3,4-tetrahydroisoquinolies (3a,b and 5a,b), 4-unsubstituted, 4-p-nitrophenyl- and 4-oxo-1- or 2-methyl-9,10-dimethoxy-2H,4H-1,6,7, 11b-tetrahydro-1,3-oxazino[4,3-a]isoquinoline diastereomers (6a,b-9a,b, 12a,b and 13a,b) 6-9, 12 and 13 were prepared. The relative configurations and the predominant conformations were determined by H-1 and C-13 NMR spectroscopy, use also being made of DR, DEPT, DNOE and 2D-HSC measurements.

引用

页码：24 / 32

页数：9

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