N-METHYL-D-ASPARTIC ACID (NMDA) RECEPTOR ANTAGONIST MK-801 BLOCKS NONOPIOID STRESS-INDUCED ANALGESIA .1. COMPARISON OF OPIATE RECEPTOR-DEFICIENT AND OPIATE RECEPTOR-RICH STRAINS OF MICE

被引：36

作者：

MAREK, P ^{[1
]}

PAGE, GG ^{[1
]}

BENELIYAHU, S ^{[1
]}

LIEBESKIND, JC ^{[1
]}

机构：

[1] UNIV CALIF LOS ANGELES,DEPT PSYCHOL,LOS ANGELES,CA 90024

来源：

BRAIN RESEARCH | 1991年 / 551卷 / 1-2期

关键词：

STRESS-INDUCED ANALGESIA; NALOXONE; MK-801; EXCITATORY AMINO ACID; N-METHYL-D-ASPARTATE;

D O I：

10.1016/0006-8993(91)90943-P

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The effects of the specific N-methyl-D-aspartic acid (NMDA) receptor antagonist MK-801 (0.075 mg/kg), and the specific opiate receptor antagonist naloxone (10 mg/kg), on swim stress-induced analgesia (SSIA) were studied in opiate receptor-deficient (CXBK) and opiate receptor-rich (CXBH) mice. Animals were subjected to forced swimming, and analgesia was assessed using the hot-plate test. In CXBK mice SSIA was blocked by MK-801 but was completely insensitive to naloxone. In CXBH mice SSIA was partially attenuated both by naloxone and MK-801, and it was nearly abolished by a combination of these drugs. Morphine analgesia (10 mg/kg) was abolished by naloxone but completely unaffected by MK-801 in CXBH mice. These findings suggest that the NMDA receptor is critically involved in the non-opioid component of SSIA.

引用

页码：293 / 296

页数：4

共 17 条

[1] NMDA RECEPTOR ANTAGONIST MK-801 BLOCKS NONOPIOID STRESS-INDUCED ANALGESIA IN THE FORMALIN TEST
VACCARINO, AL
MAREK, P
STERNBERG, W
LIEBESKIND, JC
[J]. PAIN, 1992, 50 (01) : 119 - 123
[2] N-METHYL-D-ASPARTIC ACID (NMDA) RECEPTOR ANTAGONIST MK-801 BLOCKS NONOPIOID STRESS-INDUCED ANALGESIA .2. COMPARISON ACROSS 3 SWIM-STRESS PARADIGMS IN SELECTIVELY BRED MICE
MAREK, P
MOGIL, JS
STERNBERG, WF
PANOCKA, I
LIEBESKIND, JC
[J]. BRAIN RESEARCH, 1992, 578 (1-2) : 197 - 203
[3] COMPARISON OF THE NEUROPROTECTIVE EFFECTS OF THE N-METHYL-D-ASPARTATE ANTAGONIST MK-801 AND THE OPIATE-RECEPTOR ANTAGONIST NALMEFENE IN EXPERIMENTAL SPINAL-CORD ISCHEMIA
YUM, SW
FADEN, AI
[J]. ARCHIVES OF NEUROLOGY, 1990, 47 (03) : 277 - 281
[4] THE SPECIFIC N-METHYL-D-ASPARTATE (NMDA) RECEPTOR ANTAGONIST MK-801 BLOCKS U-50,488, BUT NOT MORPHINE ANTINOCICEPTION
KEST, B
MAREK, P
LIEBESKIND, JC
[J]. BRAIN RESEARCH, 1992, 589 (01) : 139 - 142
[5] INHIBITION OF COCAINE SENSITIZATION BY MK-801, A NONCOMPETITIVE N-METHYL-D-ASPARTATE (NMDA) RECEPTOR ANTAGONIST - EVALUATION BY AMBULATORY ACTIVITY IN MICE
IDA, I
ASAMI, T
KURIBARA, H
[J]. JAPANESE JOURNAL OF PHARMACOLOGY, 1995, 69 (02): : 83 - 90
[6] MK-801, AN N-METHYL-D-ASPARTATE RECEPTOR ANTAGONIST, BLOCKS QUINOLINIC ACID-INDUCED LIPID-PEROXIDATION IN RAT CORPUS STRIATUM
SANTAMARIA, A
RIOS, C
[J]. NEUROSCIENCE LETTERS, 1993, 159 (1-2) : 51 - 54
[7] N-METHYL-D-ASPARTIC ACID RECEPTOR ANTAGONIST-INDUCED FREQUENCY OSCILLATIONS IN MICE RECREATE PATTERN OF ELECTROPHYSIOLOGICAL DEFICITS IN SCHIZOPHRENIA
Ehrlichman, R. S.
Gandal, M. J.
Maxwell, C. R.
Lazarewicz, M. T.
Finkel, L. H.
Contreras, D.
Turetsky, B. I.
Siegel, S. J.
[J]. NEUROSCIENCE, 2009, 158 (02) : 705 - 712
[8] ANTAGONISTIC EFFECTS OF THE SELECTIVE, COMPETITIVE N-METHYL-D-ASPARTATE (NMDA) RECEPTOR ANTAGONIST, NPC 12626, ON KAPPA-OPIATE-INDUCED ANALGESIA IN MALE DEER MICE
SAUCIER, DM
KAVALIERS, M
[J]. BRAIN RESEARCH, 1994, 637 (1-2) : 292 - 296
[9] N-methyl-D-aspartate receptor (NMDA-R) antagonist MK-801 suppresses TNF-α-induced endothelial activation and leukocyte recruitment
Obregon, D
Mondal, D
Murthy, S
Pradhan, L
Kukreja, P
Ali, M
Liu, K
Agrawal, K
Fonseca, V
McNamara, D
[J]. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 2005, 38 (05) : 821 - 821
[10] Dizocilpine (MK-801) induces distinct changes of N-methyl-D-aspartic acid receptor subunits in parvalbumin-containing interneurons in young adult rat prefrontal cortex
Xi, Dong
Zhang, Wentong
Wang, Huai-Xing
Stradtman, George G., III
Gao, Wen-Jun
[J]. INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY, 2009, 12 (10): : 1395 - 1408

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