CHANGES OF ADP-RIBOSYLATION OF GTP-BINDING PROTEIN BY PERTUSSIS TOXIN IN HUMAN PLATELETS DURING LONG-TERM TREATMENT OF MANIC-DEPRESSION WITH LITHIUM-CARBONATE

被引：6
|
作者：
WATANABE, Y
MORITA, H
IMAIZUMI, T
TAKEDA, M
HARIGUCHI, S
NISHIMURA, T
YOSHIDA, H
机构：
[1] OSAKA UNIV,SCH MED,DEPT PHARMACOL 1,NAKANOSHIMA 4-3-57,KITA KU,OSAKA 530,JAPAN
[2] OSAKA UNIV,SCH MED,DEPT PSYCHIAT,KITA KU,OSAKA 530,JAPAN
来源：
CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY | 1990年 / 17卷 / 11期
关键词：
ADP‐ribosylation; GTP‐binding protein; human platelet; lithium ion; manic depression; pertussis toxin;
D O I：
10.1111/j.1440-1681.1990.tb01283.x
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
1. The study was done to determine whether long‐term treatment with lithium carbonate affected the guanosine triphosphate (GTP)‐binding protein in platelet membranes from patients with manic depression. 2. It was found that adenosine diphosphate (ADP)‐ribosylation of inhibitory G‐proteins (40–41 kDa) by pertussis toxin, islet‐activating protein in the cell membranes increased about 45% when long‐term treatment with lithium carbonate was stopped. 3. These results support the idea that one site for the therapeutic effects of lithium ions is G‐proteins. Copyright © 1990, Wiley Blackwell. All rights reserved
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页码：809 / 812
页数：4
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