PRELIMINARY-RESULTS OF A PHASE-I/II STUDY OF SODIUM PENTOSANPOLYSULFATE IN THE TREATMENT OF CHRONIC RADIATION-INDUCED PROCTITIS

被引：36
|
作者：
GRIGSBY, PW
PILEPICH, MV
PARSONS, CL
机构：
[1] UNIV CALIF SAN DIEGO,MED CTR,DEPT SURG UROL,LA JOLLA,CA 92093
[2] CATHERINE MCAULEY HLTH CTR,DEPT RADIAT ONCOL,ANN ARBOR,MI
来源：
AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS | 1990年 / 13卷 / 01期
关键词：
D O I：
10.1097/00000421-199002000-00008
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
This is a report of a phase I/II study of 13 patients treated with sodium pentosanpolysulfate (PPS) for chronic radiation-induced proctitis. A complete response was obtained in 82%, a partial response occurred in 9%, and 9% failed to respond to therapy. No significant toxicity was observed. It is concluded that PPS is an effective treatment for chronic radiation-induced proctitis and a phase III randomized, double-blind study of PPS versus placebo is planned.
引用
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页码：28 / 31
页数：4
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