COMPARATIVE EFFECTS OF DIAZEPAM, FLUMAZENIL AND BUSPIRONE ON BENZODIAZEPINE WITHDRAWAL ANXIETY

被引：0
|
作者：
KORKMAZ, S
PALAOGLU, O
AYHAN, IH
机构：
来源：
NEUROSCIENCE RESEARCH COMMUNICATIONS | 1994年 / 14卷 / 03期
关键词：
DIAZEPAM; FLUMAZENIL; BUSPIRONE; WITHDRAWAL ANXIETY; ELEVATED PLUS MAZE;
D O I：
暂无
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Although it is known that tolerance develops to the anxiolytic effect of diazepam and a spontaneous withdrawal anxiogenesis appears following cessation of chronic drug administration, not only the mechanism by how tolerance develops but the extent of effects and the mechanism of action of drugs on withdrawal anxiety are not yet clearly defined. In the present study, a dose dependent anxiolytic effect of diazepam was shown via Elevated Plus Maze. While buspirone produced a significant anxiolysis flumazenil had no effect on the parameters studied, in naive rats. Not only tolerance development to the anxiolytic effect of diazepam but a significant withdrawal anxiety was shown in chronically diazepam treated rats. Diazepam was found to produce a significant anxiolysis against withdrawal anxiety, but buspirone, flumazenil and buspirone-flumazenil combination were all found to reverse the withdrawal anxiety limited to the control base line level. Diazepam and flumazenil combination was also found to produce a significant anxiolysis but not as potent as diazepam.
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页码：125 / 132
页数：8
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