REARRANGEMENT OF THE T-CELL RECEPTOR ALPHA-CHAIN, BETA-CHAIN AND GAMMA-CHAIN GENES IN CHRONIC LYMPHOCYTIC-LEUKEMIA

被引：13
|
作者：
PERL, A
DIVINCENZO, JP
RYAN, DH
GERGELY, P
SZIGETI, A
FEHER, J
ABRAHAM, GN
机构：
[1] UNIV ROCHESTER,MED CTR,DEPT MED,ROCHESTER,NY 14642
[2] UNIV ROCHESTER,MED CTR,DEPT MICROBIOL & IMMUNOL,ROCHESTER,NY 14642
[3] SEMMELWEIS UNIV MED,DEPT MED 2,BUDAPEST,HUNGARY
[4] UNIV ROCHESTER,MED CTR,DEPT PATHOL,ROCHESTER,NY 14642
来源：
LEUKEMIA RESEARCH | 1990年 / 14卷 / 02期
关键词：
beta; CLL; gamma gene rearrangements; Ig; TCR alpha;
D O I：
10.1016/0145-2126(90)90041-7
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Simultaneous expression of mature B-cell and T-cell markers and subsequent abrogation of expression of the T-cell surface markers by cytotoxic chemotherapy was reported earlier in a patient (TG) with chronic lymphocytic leukemia (CLL). In addition to rearrangements of the immunoglobulin (Ig) gene loci correlating with phenotypic data, the T-cell receptor (TCR) alpha, beta and gamma chain genes also displayed clonal rearrangements in peripheral blood lymphocyte DNA of TG. The present case shows that in CLL cells not only the expression of B-cell and T-cell specific differentiation antigens but also the rearrangement of Ig as well as TCR alpha, beta and gamma genes may occur simultaneously. © 1990.
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页码：131 / &
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