Obsessive compulsive disorder (OCD) is characterized by a vicious cycle of reoccurring intrusive, anxiety-evoking thoughts or impulses (obsessions) and repetitive behaviors (compulsions). Cognitive approaches to OCD focus on the role of cognitive biases in the onset and maintenance of this vicious cycle, with increased doubts and memory uncertainty being primary factors. Behavioral approaches, on the other hand, focus on executive dysfunctions, with inhibitory deficit being most prominent. In the current paper, we review previous literature on the presence and role of inhibitory deficits, increased doubts, and memory uncertainty in OCD, followed by evidence suggesting that these factors are highly interrelated. We propose that both inhibitory deficits and increased doubts serve as prominent components of OCD and suggest that a more integrative approach is needed in order to more fully conceptualize the etiology and maintenance cycle of OCD.
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Chicago Psychoanalyt Inst, 122 South Michigan Ave,Suite 1450, Chicago, IL 60603 USAChicago Psychoanalyt Inst, 122 South Michigan Ave,Suite 1450, Chicago, IL 60603 USA
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Butler Hosp, Dept Psychiat & Human Behav, Brown Med Sch, Providence, RI 02906 USAJohns Hopkins Univ, Sch Med, Dept Psychiat & Behav Sci, 550 N Broadway 902, Baltimore, MD 21205 USA
Greenberg, Benjamin D.
McLaughlin, Nicole C.
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Butler Hosp, Dept Psychiat & Human Behav, Brown Med Sch, Providence, RI 02906 USAJohns Hopkins Univ, Sch Med, Dept Psychiat & Behav Sci, 550 N Broadway 902, Baltimore, MD 21205 USA
McLaughlin, Nicole C.
Rasmussen, Steven A.
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Butler Hosp, Dept Psychiat & Human Behav, Brown Med Sch, Providence, RI 02906 USAJohns Hopkins Univ, Sch Med, Dept Psychiat & Behav Sci, 550 N Broadway 902, Baltimore, MD 21205 USA
Rasmussen, Steven A.
Fyer, Abby J.
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Columbia Univ, Dept Psychiat, Coll Phys & Surg, New York, NY USA
New York State Psychiat Inst & Hosp, New York, NY 10032 USAJohns Hopkins Univ, Sch Med, Dept Psychiat & Behav Sci, 550 N Broadway 902, Baltimore, MD 21205 USA
Fyer, Abby J.
Knowles, James A.
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Univ Southern Calif, Dept Psychiat, Sch Med, Los Angeles, CA USAJohns Hopkins Univ, Sch Med, Dept Psychiat & Behav Sci, 550 N Broadway 902, Baltimore, MD 21205 USA
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Univ Calif Los Angeles, Sch Med, Dept Psychiat & Behav Sci, Los Angeles, CA 90024 USAJohns Hopkins Univ, Sch Med, Dept Psychiat & Behav Sci, 550 N Broadway 902, Baltimore, MD 21205 USA
McCracken, James T.
Piacentini, John
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Univ Calif Los Angeles, Sch Med, Dept Psychiat & Behav Sci, Los Angeles, CA 90024 USAJohns Hopkins Univ, Sch Med, Dept Psychiat & Behav Sci, 550 N Broadway 902, Baltimore, MD 21205 USA
Piacentini, John
Geller, Dan
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Harvard Med Sch, Dept Psychiat, Boston, MA USAJohns Hopkins Univ, Sch Med, Dept Psychiat & Behav Sci, 550 N Broadway 902, Baltimore, MD 21205 USA
Geller, Dan
Pauls, David L.
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Massachusetts Gen Hosp, Dept Psychiat, Boston, MA 02114 USA
Massachusetts Gen Hosp, Psychiat & Neurodev Genet Unit, Boston, MA 02114 USA
Harvard Med Sch, Boston, MA USAJohns Hopkins Univ, Sch Med, Dept Psychiat & Behav Sci, 550 N Broadway 902, Baltimore, MD 21205 USA
Pauls, David L.
Stewart, S. Evelyn
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Univ British Columbia, Fac Med, Dept Psychiat, Vancouver, BC, CanadaJohns Hopkins Univ, Sch Med, Dept Psychiat & Behav Sci, 550 N Broadway 902, Baltimore, MD 21205 USA
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CNRS, Inst Malad Neurodegenerat, UMR 5293, Bordeaux, France
Univ Victor Segalen Bordeaux 2, F-33076 Bordeaux, France
Pole Univ Psychiat Adulte, Hop Charles Perrens, Bordeaux, FranceCNRS, Inst Malad Neurodegenerat, UMR 5293, Bordeaux, France
Rotge, Jean-Yves
Langbour, Nicolas
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CNRS, Inst Malad Neurodegenerat, UMR 5293, Bordeaux, France
Univ Victor Segalen Bordeaux 2, F-33076 Bordeaux, FranceCNRS, Inst Malad Neurodegenerat, UMR 5293, Bordeaux, France
Langbour, Nicolas
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Dilharreguy, Bixente
Bordessoulles, Martine
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Univ Victor Segalen Bordeaux 2, F-33076 Bordeaux, France
CNRS, Inst Neurosci Cognit & Integrat Aquita, Bordeaux, France
Hop Pellegrin, Nucl Med Serv, F-33076 Bordeaux, France
Hop Pellegrin, Serv Neurophysiol, F-33076 Bordeaux, FranceCNRS, Inst Malad Neurodegenerat, UMR 5293, Bordeaux, France
Bordessoulles, Martine
Guehl, Dominique
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CNRS, Inst Malad Neurodegenerat, UMR 5293, Bordeaux, France
Univ Victor Segalen Bordeaux 2, F-33076 Bordeaux, France
Ctr Invest Clin, INSERM, U 802, Poitiers, FranceCNRS, Inst Malad Neurodegenerat, UMR 5293, Bordeaux, France
Guehl, Dominique
Bioulac, Bernard
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CNRS, Inst Malad Neurodegenerat, UMR 5293, Bordeaux, France
Univ Victor Segalen Bordeaux 2, F-33076 Bordeaux, France
Ctr Invest Clin, INSERM, U 802, Poitiers, FranceCNRS, Inst Malad Neurodegenerat, UMR 5293, Bordeaux, France
Bioulac, Bernard
Martin-Guehl, Corinne
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Univ Victor Segalen Bordeaux 2, F-33076 Bordeaux, FranceCNRS, Inst Malad Neurodegenerat, UMR 5293, Bordeaux, France
Martin-Guehl, Corinne
Jaafari, Nematollah
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INSERM, Equipe AVENIR Psychobiol Troubles Compulsifs, Lab Neurosci Expt & Clin, U 1084, Poitiers, France
Univ Poitiers, Poitiers, France
Ctr Hosp Univ, Poitiers, France
Hop Henri Laborit, Unite Rech Clin Intersectorielle Psychiat, Poitiers, FranceCNRS, Inst Malad Neurodegenerat, UMR 5293, Bordeaux, France
Jaafari, Nematollah
Aouizerate, Bruno
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Univ Victor Segalen Bordeaux 2, F-33076 Bordeaux, France
Pole Univ Psychiat Adulte, Hop Charles Perrens, Bordeaux, FranceCNRS, Inst Malad Neurodegenerat, UMR 5293, Bordeaux, France
Aouizerate, Bruno
Allard, Michele
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Univ Victor Segalen Bordeaux 2, F-33076 Bordeaux, France
CNRS, Inst Neurosci Cognit & Integrat Aquita, Bordeaux, France
Hop Pellegrin, Nucl Med Serv, F-33076 Bordeaux, France
Hop Pellegrin, Serv Neurophysiol, F-33076 Bordeaux, FranceCNRS, Inst Malad Neurodegenerat, UMR 5293, Bordeaux, France
Allard, Michele
Burbaud, Pierre
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CNRS, Inst Malad Neurodegenerat, UMR 5293, Bordeaux, France
Univ Victor Segalen Bordeaux 2, F-33076 Bordeaux, France
Ctr Invest Clin, INSERM, U 802, Poitiers, FranceCNRS, Inst Malad Neurodegenerat, UMR 5293, Bordeaux, France
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Department of Psychology, Case Western Reserve University, Laurelwood Counseling Ctr. Univ. C., Cleveland, OH 44106-7123Department of Psychology, Case Western Reserve University, Laurelwood Counseling Ctr. Univ. C., Cleveland, OH 44106-7123
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University of Pennsylvania School of Medicine, Center for the Treatment and Study of Anxiety, Philadelphia, PA 19104University of Pennsylvania School of Medicine, Center for the Treatment and Study of Anxiety, Philadelphia, PA 19104
Huppert J.D.
Franklin M.E.
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University of Pennsylvania School of Medicine, Center for the Treatment and Study of Anxiety, Philadelphia, PA 19104University of Pennsylvania School of Medicine, Center for the Treatment and Study of Anxiety, Philadelphia, PA 19104