IN-VIVO GENETIC STABILITY OF SALMONELLA-TYPHI DETECTED BY RIBOTYPING AND PULSED-FIELD GEL-ELECTROPHORESIS

被引：0
|
作者：
THONG, KL
PUTHUCHEARY, SD
PANG, T
机构：
[1] UNIV MALAYA,CTR FDN STUDIES SCI,KUALA LUMPUR,MALAYSIA
[2] UNIV MALAYA,DEPT MED MICROBIOL,KUALA LUMPUR,MALAYSIA
[3] UNIV MALAYA,INST ADV STUDIES,KUALA LUMPUR,MALAYSIA
来源：
ASIA-PACIFIC JOURNAL OF MOLECULAR BIOLOGY AND BIOTECHNOLOGY | 1995年 / 3卷 / 04期
关键词：
D O I：
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中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Ribotyping PCR-ribotyping and pulsed-field gel electrophoresis were used to analyze five serial isolates of Salmonella typhi obtained from a single patient with relapsing typhoid fever over a 7-week period. The 5 isolates were genetically identical by all three methods thus suggesting relapsing infection with the same strain and implying in vivo genomic stability of S. typhi even in the presence of selective pressures of antibiotic treatment and host defenses.
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页码：356 / 361
页数：6
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