AROMATIC AMINO-ACID PHOSPHORAMIDATE DIESTERS AND TRIESTERS OF 3'-AZIDO-3'-DEOXYTHYMIDINE (AZT) ARE NONTOXIC INHIBITORS OF HIV-1 REPLICATION

被引：54
|
作者：
WAGNER, CR [1 ]
MCINTEE, EJ [1 ]
SCHINAZI, RF [1 ]
ABRAHAM, TW [1 ]
机构：
[1] EMORY UNIV,VET ADM MED CTR,SCH MED,DEPT PEDIAT,DECATUR,GA 30033
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1995年 / 5卷 / 16期
关键词：
D O I：
10.1016/0960-894X(95)00302-A
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A series of aromatic, water soluble and non-toxic amino acid phosphoramidate di- and triesters of zidovudine (AZT) were shown to inhibit the replication of HIV-1 in human peripheral blood mononuclear cells (PBMC). Cells treated with the active AZT diesters contained four fold more phosphorylated AZT than those treated with AZT, and no free AZT.
引用
收藏
页码：1819 / 1824
页数：6
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