INTERACTION OF INTERLEUKIN-2 AND INTERLEUKIN-4 DURING LAK CELL GENERATION

被引：0

作者：

INDROVA, M

JANDLOVA, T

BUBENIK, J

机构：

来源：

FOLIA BIOLOGICA | 1992年 / 38卷 / 01期

关键词：

INTERLEUKIN-2; INTERLEUKIN-4; LAK CELLS;

D O I：

暂无

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Immunoregulatory lymphokines IL-2 and IL-4 produced by IL-2- and IL-4-cDNA-transformed somatic cells were used for LAK cell generation. The cytolytic effect of LAK cells activated for 3 days with IL-2 and measured by Cr-51 release of three types of target cells, YAC-1 (NK-sensitive), C1498 (NK-resistant) and X63-Ag8.653 (plasmocytoma cell line utilized for insertion of the IL-2 and Il-4 genes), was significantly depressed by adding IL-4 during the activation period.

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页数：9

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