ENDOTHELIN-1 STIMULATES ARACHIDONATE 15-LIPOXYGENASE ACTIVITY AND OXYGEN RADICAL FORMATION IN THE RAT DISTAL LUNG

被引：70

作者：

NAGASE, T ^{[1
]}

FUKUCHI, Y ^{[1
]}

JO, C ^{[1
]}

TERAMOTO, S ^{[1
]}

UEJIMA, Y ^{[1
]}

ISHIDA, K ^{[1
]}

SHIMIZU, T ^{[1
]}

ORIMO, H ^{[1
]}

机构：

[1] UNIV TOKYO,FAC MED,DEPT PHYSIOL CHEM & NUTR,BUNKYO KU,TOKYO 113,JAPAN

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1990年 / 168卷 / 02期

关键词：

D O I：

10.1016/0006-291X(90)92347-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We investigated the effects of intravenous bolus of endothelin-1 on the metabolism of eicosanoids and oxygen radicals in the distal lung unit of the rat. Intravenous bolus of endothelin-1 caused a significant increase in 15-hydroxyeicosatetraenoic acid of bronchoalveolar lavage fluid and oxygen radicals produced by the bronchoalveolar cells. Endothelin-1 exhibited a stimulatory effect on the 15-lipoxygenase activity in the lung homogenate. Thus, endothelin-1 may contribute to the inflammatory and hyperreactive process of lungs, by enhancing the release of 15-hydroxyeicosatetraenoic acid and oxygen radicals in the distal lung unit. © 1990.

引用

页码：485 / 489

页数：5

共 7 条

[1] ENDOTHELIN-1 ACUTELY STIMULATES THE SECRETORY ACTIVITY OF RAT ZONA GLOMERULOSA CELLS
MAZZOCCHI, G
MALENDOWICZ, LK
NUSSDORFER, GG
PEPTIDES, 1990, 11 (04) : 763 - 765
[2] Endothelin-1 stimulates eNOS expression and activity in rat pulmonary microvascular endothelial cells.
Liu, LC
Luo, B
Wang, ZS
Abrams, GA
Fallon, MB
HEPATOLOGY, 2001, 34 (04) : 184A - 184A
[3] Innocuous Levels of Pulmonary Thrombosis Protect Against Inflammatory Lung Injury via Endothelial Arachidonate 15-Lipoxygenase and Hypoxia-Inducible Factor 1α
Evans, Colin E.
Zhang, Xianming
Machireddy, Narsa
Zhao, Youyang
CIRCULATION, 2021, 144
[4] ENDOTHELIN-1 STIMULATES PROTEIN-KINASE-C ACTIVITY AND PROTEIN TYROSINE PHOSPHORYLATION IN RAT-1 FIBROBLASTS
SAVILLE, MK
MALARKEY, K
GOULD, GW
PLEVIN, R
BRITISH JOURNAL OF PHARMACOLOGY, 1993, 108 : P109 - P109
[5] ENDOTHELIN-1 STIMULATES CYTOSOLIC PHOSPHOLIPASE A(2) ACTIVITY AND GENE-EXPRESSION IN RAT GLOMERULAR MESANGIAL CELLS
SCHRAMEK, H
WANG, YZ
KONIECZKOWSKI, M
SIMONSON, MS
DUNN, MJ
KIDNEY INTERNATIONAL, 1994, 46 (06) : 1644 - 1652
[6] HYPOXIA STIMULATES ENDOTHELIN-1 GENE-EXPRESSION IN RAT LUNG AND IN CULTURED PORCINE PULMONARY-ARTERY ENDOTHELIAL-CELLS
LI, HB
ELTON, TS
CHEN, YF
OPARIL, S
FASEB JOURNAL, 1993, 7 (04): : A650 - A650
[7] Inhibition of rat and human cytochrome P4502E1 catalytic activity and reactive oxygen radical formation by nitric oxide
Gergel, D
Misik, V
Riesz, P
Cederbaum, AI
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1997, 337 (02) : 239 - 250

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