PREPARATION AND CHARACTERIZATION OF LECTIN-LATEX CONJUGATES FOR SPECIFIC BIOADHESION

被引：58
|
作者：
IRACHE, JM [1 ]
DURRER, C [1 ]
DUCHENE, D [1 ]
PONCHEL, G [1 ]
机构：
[1] UNIV PARIS SUD,PHARM GALEN & BIOPHARM LAB,CNRS,URA 1218,F-92296 CHATENAY MALABRY,FRANCE
来源：
BIOMATERIALS | 1994年 / 15卷 / 11期
关键词：
LECTIN; BIOADHESION; LATEX; NANOPARTICLES; MUCIN;
D O I：
10.1016/0142-9612(94)90114-7
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
This paper reports on the preparation and characterization of certain bioadhesive model drug delivery systems formed by a carrier (e.g. modified nanoparticles of polystyrene) and a ligand (e.g. tomato lectin, asparagus pea lectin, Mycoplasma gallisepticum lectin or albumin). Three different manufacturing methods (carbodiimide and glutaraldehyde coupling and physical adsorption) were studied. The activity of the lectin-latex conjugates and albumin-latex conjugate (control) were tested with gastric pig mucin. The manufacturing method had an insignificant effect on the activity, but all lectin-latex conjugates interacted two or three times more with mucin than with the control.
引用
收藏
页码：899 / 904
页数：6
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