NICOTINE INHIBITS CYTOKINE SYNTHESIS BY MOUSE COLONIC MUCOSA

被引：52

作者：

VANDIJK, JPM ^{[1
]}

MADRETSMA, GS ^{[1
]}

KEUSKAMP, ZJ ^{[1
]}

ZIJLSTRA, FJ ^{[1
]}

机构：

[1] ERASMUS UNIV ROTTERDAM,FAC MED & HLTH SCI,DEPT PHARMACOL,3000 DR ROTTERDAM,NETHERLANDS

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1995年 / 278卷 / 01期

关键词：

NICOTINE; COLONIC MUCOSA; CYTOKINE;

D O I：

10.1016/0014-2999(95)00211-3

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

We examined the in vivo effect of nicotine on the synthesis of (pro-)inflammatory mediators by mouse colonic mucosa. The synthesis of lipid mediators such as the prostanoids prostaglandin E(2), 6-keto-prostaglandin F-1 alpha and thromboxane B-2, the 5-lipoxygenase products leukotriene B-4 and leukotriene C-4, and the platelet activating factor was not affected, whereas the synthesis of the pro-inflammatory cytokines interleukin-1 beta and tumor necrosis factor alpha was completely abolished. The beneficial effects of smoking and nicotine in ulcerative colitis could be attributed to this inhibition.

引用

页码：R11 / R12

页数：2

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