IMPACT OF ANTIDEPRESSANTS ON LIPID-METABOLISM AND CLINICAL-PATTERN OF CORONARY HEART-DISEASE

The addition of antidepressants to combined treatment of IHD patients aroused not only mediated psychic benefit, but also positive shifts in metabolic and mediator regulation of chronic psychoemotional stress. Antidepressants administration results in lowering of total blood cholesterol and atherogenic lipoproteins, inhibits LPO, promotes normalization of cyclic nucleotides levels (cAMP and cGMP increase and decrease, respectively). Clinical course of the disease also improved (less frequent and severe attacks of angina pectoris and associated atypical pain syndrome, of arrhythmia paroxysms; exercise tolerance increased, hemodynamics improved). The arguments in favour of antidepressant use in coronary patients with anxiodepressive symptoms and social and psychological dysadaptation are provided.