MOLECULAR CHARACTERIZATION OF G-PROTEIN COUPLED RECEPTORS - ISOLATION AND CLONING OF A D1 DOPAMINE RECEPTOR

被引：9
|
作者：
GINGRICH, JA [1 ]
DEARRY, A [1 ]
FALARDEAU, P [1 ]
FREMEAU, RT [1 ]
BATES, MD [1 ]
CARON, MG [1 ]
机构：
[1] DUKE UNIV,MED CTR,DEPT MED,DURHAM,NC 27710
来源：
JOURNAL OF RECEPTOR RESEARCH | 1991年 / 11卷 / 1-4期
关键词：
D O I：
10.3109/10799899109066425
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
This article summarizes the recent progress our laboratory has made in understanding the molecular characteristics of the D1 dopamine receptor. The D1 dopamine receptor from rat striatum has been purified to near homogeneity using a combination of several chromatographic steps. Furthermore, the gene for the human D1 dopamine receptor has been cloned, sequenced, and expressed. The cloned receptor has all the pharmacologic and biochemical properties of the classical D1 receptor coupled to adenylyl cyclase which has been previously described in the central nervous system.
引用
收藏
页码：521 / 534
页数：14
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