APOLIPOPROTEIN-E PHENOTYPES AND HYPERLIPIDEMIA IN PATIENTS UNDER MAINTENANCE HEMODIALYSIS

被引：2

作者：

FEUSSNER, G ^{[1
]}

WEY, S ^{[1
]}

BOMMER, J ^{[1
]}

DEPPERMANN, D ^{[1
]}

GRUTZMACHER, P ^{[1
]}

ZIEGLER, R ^{[1
]}

机构：

[1] ST MARKUS HOSP,MED KLIN,W-6000 FRANKFURT,GERMANY

来源：

HUMAN GENETICS | 1992年 / 88卷 / 03期

关键词：

D O I：

暂无

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Apolipoprotein E phenotypes and gene frequencies were determined in 560 patients receiving long-term hemodialysis. In addition, fasting plasma lipid- and apolipoprotein-concentrations were evaluated in 245 of these individuals. The distribution of the three major apolipoprotein E alleles (epsilon-4, epsilon-3, and epsilon-2) and that of the six common apolipoprotein E phenotypes (E4/4, E3/3, E2/2, E4/2, E4/3, and E3/2) in the dialysis group was nearly identical to that of healthy controls. Patients with the apolipoprotein E phenotypes E2/2, E4/4 and E4/3 (comprising 24% of the whole group) had higher mean plasma cholesterol- and triglyceride-concentrations than those with the apolipoprotein E phenotypes E3/3 and E3/2 (72% of the whole group). Thus, the genetic polymorphism of apolipoprotein E may contribute to the individual risk of accelerated atherosclerosis in patients under maintenance hemodialysis.

引用

页码：307 / 312

页数：6

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