SYNTHESIS AND BIOLOGICAL EVALUATION OF 14-ALKOXYMORPHINANS .8. 14-METHOXYMETOPON, AN EXTREMELY POTENT OPIOID AGONIST

被引：44
|
作者：
SCHMIDHAMMER, H
SCHRATZ, A
MITTERDORFER, J
机构：
[1] Institute of Organic and Pharmaceutical Chemistry, University of Innsbruck, Innsbruck, A-6020
来源：
HELVETICA CHIMICA ACTA | 1990年 / 73卷 / 06期
关键词：
D O I：
10.1002/hlca.19900730623
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
14‐Methoxymetopon (= 5,14‐O‐dimethyloxymorphone; 4)and 14‐ethoxymetopon (5) were synthesized from 14‐hydroxy‐5‐methylcodeinone (6). In the AcOH‐writhing test in mice, compound 4 was found to be ca. 20000 times more potent than morphine. Copyright © 1990 Verlag GmbH & Co. KGaA, Weinheim
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页码：1784 / 1787
页数：4
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