PHASE-II STUDY OF ACNU AS 1ST-LINE TREATMENT IN ADVANCED COLORECTAL-CANCER

被引：0
|
作者：
PLANTING, A
HOFF, A
VANDERBURG, M
VERWEIJ, J
STOTER, G
机构：
[1] Department of Medical Oncology, Rotterdam Cancer Center Dr. Daniel den Hoed Kliniek, Rotterdam
来源：
ANNALS OF ONCOLOGY | 1991年 / 2卷 / 10期
关键词：
PHASE II; COLORECTAL CANCER; ACNU;
D O I：
10.1093/oxfordjournals.annonc.a057862
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Thirty-two patients with metastatic colorectal cancer were entered in a phase II study of ACNU as first-line treatment. ACNU was given at a dose of 100 mg/m2 i.v. every six weeks. In 30 evaluable patients we observed partial responses lasting 5 and 8 months in 2 patients with liver metastases, and stable disease in 4 patients. The toxicity mainly consisted of leuco- and trombocytopenia. We conclude that in this dose and schedule ACNU has only very limited activity in metastatic colorectal cancer.
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收藏
页码：767 / 768
页数：2
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