TRANSFORMING GROWTH-FACTOR-BETA INHIBITS THE ANTIVIRAL ACTION OF INTERFERONS IN HUMAN EMBRYONIC FIBROBLASTS

被引：6
|
作者：
ZIELINSKAJENCZYLIK, J [1 ]
INGLOT, AD [1 ]
INGLOT, O [1 ]
POPIK, W [1 ]
机构：
[1] POLISH ACAD SCI,LUDWIK HIRSZFELD INST IMMUNOL & EXPTL THERAPY,VIROL LAB,CZERSKA 12,PL-53114 WROCLAW,POLAND
来源：
JOURNAL OF INTERFERON RESEARCH | 1991年 / 11卷 / 02期
关键词：
D O I：
10.1089/jir.1991.11.87
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Transforming growth factor-beta (TGF-beta) at concentration of 10 ng/ml inhibited the development of the interferon-alpha- (IFN-alpha) or IFN-gamma-induced antiviral state in quiescent human embryonic fibroblasts. The action of the cytokines was dose-related; TGF-beta had no direct effect on the replication of either vesicular stomatitis virus (VSV) or encephalomyocarditis virus (EMCV) used as the challenge viruses in the IFN assays. We suggest that despite the fact that TGF-beta acts mainly as a "negative" growth factor, its interactions with IFNs in the antiviral assays resemble known effects of the typical "positive" peptide growth factors.
引用
收藏
页码：87 / 89
页数：3
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