LACK OF ASSOCIATION BETWEEN THE I/D POLYMORPHISM OF THE ANGIOTENSIN-CONVERTING ENZYME GENE AND ESSENTIAL-HYPERTENSION IN A BELGIAN POPULATION

被引:0
|
作者
GU, XX [1 ]
SPAEPEN, M [1 ]
GUO, CY [1 ]
FAGARD, R [1 ]
AMERY, A [1 ]
LIJNEN, P [1 ]
CASSIMAN, JJ [1 ]
机构
[1] CATHOLIC UNIV LEUVEN,CTR HUMAN GENET,HERESTR 49,B-3000 LOUVAIN,BELGIUM
关键词
ACE GENE; HYPERTENSION;
D O I
暂无
中图分类号
R6 [外科学];
学科分类号
1002 ; 100210 ;
摘要
We tested the insertion/deletion (I/D) polymorphism of the ACE gene in 119 hypertensive patients and in 109 normotensive controls by means of the polymerase chain reaction (PCR). The allele and genotype frequencies of the I/D polymorphism in the ACE gene are essentially identical in both groups, regardless of age or sex. The I/D polymorphism of the ACE gene is thus not implicated in Belgian hypertensive patients.
引用
收藏
页码:683 / 685
页数:3
相关论文
共 50 条
  • [1] ANGIOTENSIN-CONVERTING ENZYME POLYMORPHISM AND ESSENTIAL-HYPERTENSION
    MORISE, T
    TAKEUCHI, Y
    TAKEDA, R
    [J]. LANCET, 1994, 343 (8889): : 125 - 125
  • [2] ASSOCIATION OF A POLYMORPHISM OF THE ANGIOTENSIN I-CONVERTING ENZYME GENE WITH ESSENTIAL-HYPERTENSION
    ZEE, RYL
    LOU, YK
    GRIFFITHS, LR
    MORRIS, BJ
    [J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1992, 184 (01) : 9 - 15
  • [3] Lack of association of the angiotensin converting enzyme gene polymorphism with essential hypertension in a Chinese population
    Chiang, FT
    Lai, ZP
    Chern, TH
    Tseng, CD
    Hsu, KL
    Lo, HM
    Tseng, YZ
    [J]. AMERICAN JOURNAL OF HYPERTENSION, 1997, 10 (02) : 197 - 201
  • [4] ASSOCIATION ANALYSIS OF A POLYMORPHISM OF THE ANGIOTENSIN CONVERTING ENZYME GENE WITH ESSENTIAL-HYPERTENSION IN THE JAPANESE POPULATION
    HIGASHIMORI, K
    ZHAO, Y
    HIGAKI, J
    KAMITANI, A
    KATSUYA, T
    NAKURA, J
    MIKI, T
    MIKAMI, H
    OGIHARA, T
    [J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1993, 191 (02) : 399 - 404
  • [5] Angiotensin-converting enzyme gene polymorphism and its association with essential hypertension in a Tibetan population
    Gesang, L
    Liu, GZ
    Cen, WJ
    Qiu, CC
    Zhuoma, C
    Zhuang, LP
    Ren, D
    Pincuo, Z
    Chan, Y
    [J]. HYPERTENSION RESEARCH, 2002, 25 (03) : 481 - 485
  • [6] Association of essential hypertension in elderly Japanese with I/D polymorphism of the angiotensin-converting enzyme (ACE) gene
    Yoshida, K
    Ishigami, T
    Nakazawa, I
    Ohno, A
    Tamura, K
    Fukuoka, M
    Mizushima, S
    Umemura, S
    [J]. JOURNAL OF HUMAN GENETICS, 2000, 45 (05) : 294 - 298
  • [7] Association of essential hypertension in elderly Japanese with I/D polymorphism of the angiotensin-converting enzyme (ACE) gene
    K. Yoshida
    T. Ishigami
    I. Nakazawa
    A. Ohno
    K. Tamura
    M. Fukuoka
    S. Mizushima
    S. Umemura
    [J]. Journal of Human Genetics, 2000, 45 : 294 - 298
  • [8] Angiotensin-converting enzyme gene I/D polymorphism in malignant hypertension
    Stefansson, B
    Ricksten, A
    Rymo, L
    Aurell, M
    Herlitz, H
    [J]. BLOOD PRESSURE, 2000, 9 (2-3) : 104 - 109
  • [9] Influence of the I/D polymorphism of the angiotensin-converting enzyme gene on the outcome of microalbuminuria in essential hypertension
    Redon, J
    Chaves, FJ
    Liao, YL
    Pascual, JM
    Rovira, E
    Armengod, ME
    Cooper, RS
    [J]. HYPERTENSION, 2000, 35 (01) : 490 - 495
  • [10] Lack of association between angiotensin-converting enzyme gene polymorphism and type I aortic dissection
    Tangurek, B.
    Ketenci, B.
    Ozay, B.
    Ozer, N.
    Yilmaz, H.
    Sayar, N.
    Ciloglu, F.
    Gorur, A.
    Bolca, O.
    [J]. JOURNAL OF INTERNATIONAL MEDICAL RESEARCH, 2008, 36 (04) : 714 - 720