SYNTHESIS OF F-18 LABELED 1,1-DIFLUORO-2,2-DICHLOROETHYL ARYL ETHERS BY F-18 FOR-F-19 EXCHANGE

被引：8
|
作者：
KILBOURN, MR
SUBRAMANIAN, R
机构：
[1] Division of Nuclear Medicine, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan
来源：
JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS | 1990年 / 28卷 / 12期
关键词：
D O I：
10.1002/jlcr.2580281202
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
Fluorine‐18 labeled 1,1‐difluoro‐2,2‐dichloroethyl aryl ethers have been prepared by a facile 18F‐for‐19F isotopic exchange reaction. The isotopic exchange proceeds in good to excellent yields (up to 85%), and is dependent on reaction time, temperature, and concentration of reactants (aryl ether or fluoride ion). Substitution even occurs at room temperature in DMSO, and at elevated temperature (100 to 155°C) in DMSO or acetonitrile containing up to 20% water. Specific activities of 0.5‐55 Ci/mol have been achieved, with the products obtained in pure radiochemical and chemical form. Copyright © 1990 John Wiley & Sons, Ltd.
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收藏
页码：1355 / 1361
页数：7
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