Microdialysis: Opportunities and Prospects in Liver Transplantation (Review)

被引：0

作者：

Sushkov, A. I. ^{[1
]}

Voskanyan, S. E. ^{[2
,3
]}

Gubarev, K. K. ^{[4
]}

机构：

[1] Fed Biol Agcy, AI Burnasyan Fed Med Biophys Ctr, State Res Ctr, Surg & Transplantat Ctr,New Surg Technol Lab, 23 Marshal Novikov St, Moscow 123098, Russia

[2] Fed Biol Agcy, AI Burnasyan Fed Med Biophys Ctr, State Res Ctr, Surg, 23 Marshal Novikov St, Moscow 123098, Russia

[3] Fed Biol Agcy, AI Burnasyan Fed Med Biophys Ctr, State Res Ctr, Surg & Transplantat Ctr, 23 Marshal Novikov St, Moscow 123098, Russia

[4] Fed Biol Agcy, AI Burnasyan Fed Med Biophys Ctr, Coordinat Ctr Human Organ & Tissue Donat, State Res Ctr,Surg & Transplantat Ctr, 23 Marshal Novikov St, Moscow 123098, Russia

来源：

SOVREMENNYE TEHNOLOGII V MEDICINE | 2018年 / 10卷 / 03期

基金：

俄罗斯科学基金会;

关键词：

organ transplantation; liver transplantation; microdialysis; glucose; lactate; pyruvate; glycerol;

D O I：

10.17691/stm2018.10.3.23

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The assessment of donor organ quality and the initial graft function is of crucial importance, especially in liver transplantation. Recent studies have shown the feasibility of microdialysis to monitor energy metabolism in renal and liver grafts. This method is powerful and suitable to study chemical composition of interstitial fluid. It is possible to identify organ-related changes that occur early and are not reflected by changes in plasma. Currently, microdialysis is primarily applied in neurology and neurosurgery to assess the volume and severity of the brain tissue injury. The use of the technique to study the mechanisms of ischemia-reperfusion graft injury and the processes of early allograft dysfunction is a promising research trend. The review presents the findings of both experimental and clinical trials, and discusses the advisability and prospects of microdialysis monitoring in liver transplantation.

引用

页码：184 / 191

页数：8

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