SYNTHESIS, CHARACTERIZATION AND IN VITRO ANTICANCER EVALUATION OF BIS-[1,5]-BENZOTHIAZEPINES AGAINST HUMAN BREAST CANCER CELL LINE MCF-7

被引：4

作者：

Deshmukh, R. N. ^{[1
]}

Dengle, R. V. ^{[2
]}

机构：

[1] Bharati Vidyapeeth Coll Engn, Kolhapur 416004, Maharashtra, India

[2] Vivekanand Coll, Dept Chem, Kolhapur 416003, Maharashtra, India

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICAL SCIENCES AND RESEARCH | 2016年 / 7卷 / 12期

关键词：

2-aminobenzenethiol; bis-chalcone; 1,5-benzothiazepine; anticancer;

D O I：

10.13040/IJPSR.0975-8232.7(12).5024-29

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Bis-[1,5]-benzothiazepines (3a-i) containing two 1,5-benzothiazepine nuclei in a single molecule were synthesized by cyclocondensation reaction of bis-chalcones (1a-i) with two equivalent of 2-aminobenzenethiol (2). All the synthesized compounds were characterized by IR, H-1 NMR, C-13 NMR and mass spectral analysis. Anticancer activity of the synthesized compounds against human breast cancer cell line MCF-7 was determined and the compound (3c) showed significant activity comparable to 5-fluorouracil.

引用

页码：5024 / 5029

页数：6

共 50 条

[1] Design, Synthesis and In Vitro Evaluation of 18β-Glycyrrhetinic Acid Derivatives for Anticancer Activity Against Human Breast Cancer Cell Line MCF-7
Yadav, Dharmendra Kumar
Kalani, Komal
Singh, Abhishek K.
Khan, Feroz
Srivastava, Santosh K.
Pant, Aditya B.
[J]. CURRENT MEDICINAL CHEMISTRY, 2014, 21 (09) : 1160 - 1170
[2] Molecular docking, synthesis and anticancer activity of thiosemicarbazone derivatives against MCF-7 human breast cancer cell line
Sibuh, Belay Zeleke
Khanna, Sonia
Taneja, Pankaj
Sarkar, Paratpar
Taneja, Neetu Kumra
[J]. LIFE SCIENCES, 2021, 273
[3] IN VITRO ANTICANCER ACTIVITY OF GMELINA ASIATICA L. LEAF AGAINST HUMAN BREAST CANCER CELL LINE (MCF-7)
Florence, A. R.
Jeeva, S.
[J]. INTERNATIONAL JOURNAL OF PHARMACEUTICAL SCIENCES AND RESEARCH, 2016, 7 (05): : 2116 - 2121
[4] Synthesis, Molecular Docking, and Anticancer Evaluation of New Azo-Based Sulfonamides against MCF-7 Human Breast Cancer Cell Line
Rezaeianzadeh, Olia
Asghari, Sakineh
Tajbakhsh, Mahmood
Mohseni, Mojtaba
Khalilpour, Asieh
[J]. CHEMICAL METHODOLOGIES, 2024, 8 (05): : 329 - 350
[5] Synthesis, characterization and in vitro toxicity evaluation of doxorubicin-loaded magnetoliposomes on MCF-7 breast cancer cell line
Askari, Alireza
Tajvar, Samira
Nikkhah, Maryam
Mohammadi, Soheila
Hosseinkhani, Saman
[J]. JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY, 2020, 55
[6] Cerium Oxide/Graphene Oxide Hybrid: Synthesis, Characterization, and Evaluation of Anticancer Activity in a Breast Cancer Cell Line (MCF-7)
Saranya, J.
Saminathan, P.
Ankireddy, Seshadri Reddy
Shaik, Mohammed Rafi
Khan, Mujeeb
Khan, Merajuddin
Shaik, Baji
[J]. BIOMEDICINES, 2023, 11 (02)
[7] Anticancer effect of Illicium verum (star anise fruit) against human breast cancer MCF-7 cell line
Pahore, Asra Khan
Khan, Shagufta
Karim, Nasim
[J]. PAKISTAN JOURNAL OF MEDICAL SCIENCES, 2023, 39 (01) : 70 - 74
[8] Synthesis of quercetin derivatives as cytotoxic against breast cancer MCF-7 cell line in vitro and in silico studies
Khan, Muhammad Rizwan
Khan, Mohsin Abbas
Ahmad, Irshad
Ahmed, Javed
Ahmed, Hammad
Mubeen, Iqra
Awan, Breena
Ullah, Farhat
[J]. FUTURE MEDICINAL CHEMISTRY, 2024, 16 (17) : 1749 - 1759
[9] Antipsychotics drug aripiprazole as a lead against breast cancer cell line (MCF-7) in vitro
Badran, Adnan
tul-Wahab, Atia
Zafar, Humaira
Mohammad, Nayab
Imad, Rehan
Ashfaq Khan, Mariam
Baydoun, Elias
Choudhary, M. Iqbal
[J]. PLOS ONE, 2020, 15 (08):
[10] Diethylenetriamine Pentaacetic Acid Derivative of Toremifene and In Vitro Evaluation in Human Breast Cancer Cell Line MCF-7
Kilcar, Ayfer Yurt
Muftuler, F. Zumrut Biber
Unak, Perihan
Avci, Cigir Biray
Gunduz, Cumhur
[J]. CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS, 2011, 26 (01) : 105 - 111

← 1 2 3 4 5 →