Role of adult resident renal progenitor cells in tubular repair after acute kidney injury

被引:9
|
作者
Wang, Hui-ling [1 ,2 ]
Liu, Nan-mei [1 ,2 ]
Li, Rui [1 ,2 ]
机构
[1] 455th Hosp, Dept Nephrol, Shanghai 200052, Peoples R China
[2] Inst Nephrol Nanjing Mil Command, Shanghai 200052, Peoples R China
来源
JOURNAL OF INTEGRATIVE MEDICINE-JIM | 2014年 / 12卷 / 06期
基金
中国国家自然科学基金;
关键词
acute kidney injury; stem cell; regeneration; adult renal progenitor cells; reviews;
D O I
10.1016/S2095-4964(14)60053-4
中图分类号
R [医药、卫生];
学科分类号
10 ;
摘要
Acute kidney injury is a serious global health problem and determinant of morbidity and mortality. Recent advancements in the field of stem cell research raise hopes for stem cell-based regenerative approaches to treat acute kidney diseases. In this review, the authors summarized the latest research advances of the adult resident renal progenitor cells (ARPCs) on kidney repair, the role of ARPCs on tubular regeneration after acute kidney injury, the current understanding of the mechanisms related to ARPC activation and modulation, as well as the challenges that remain to be faced.
引用
收藏
页码:469 / 475
页数:7
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